Which layer of tissue is most involved in Dupuytren's Contracture?

Dupuytren's Contracture primarily affects the palmar aponeurosis, which is a thick connective tissue structure located in the palm of the hand. In this condition, there is a pathological shortening and thickening of the palmar aponeurosis due to excessive collagen deposition, leading to the formation of nodules and cords that can pull the fingers toward the palm.

This progressive condition primarily involves the fibrous tissue within the palmar aponeurosis rather than the epidermal or dermal layers, flexor tendons, or carpal ligaments. While the dermis provides structural support and the flexor tendons are involved in finger movement, they do not undergo the specific pathological changes that characterize Dupuytren's Contracture. The carpal ligament serves as an attachment point and does not directly relate to the contraction of fingers associated with this disorder. Thus, the palmar aponeurosis is the layer most directly involved in the development and progression of Dupuytren's Contracture.