What is the progression order of Guillain-Barré syndrome?

Guillain-Barré syndrome (GBS) is characterized by a specific pattern of progression that typically starts with symptoms in the legs and then ascends to involve higher areas of the body. This ascending order of weakness often follows an initial phase of sensory symptoms that can include tingling or numbness, usually beginning in the distal portions of the limbs.

As the condition progresses, patients often experience a decline in muscle strength that begins at the feet and may extend upwards to the trunk and even affect respiratory muscles in more severe cases. This ascending nature is a hallmark of GBS and is important for diagnosis and understanding its clinical course.

In contrast, other options do not accurately describe the typical progression of Guillain-Barré syndrome. For instance, a descending order would imply weakness starting at the top of the body and moving downwards, which is not the case for GBS. Static order would suggest that the condition remains constant without progression, which is not characteristic of GBS as it typically fluctuates and progresses over time. A mixed order does not effectively encapsulate the orderly, predictable progression observed in this syndrome. Therefore, the ascending order reflects the typical clinical presentation and progression of Guillain-Barré syndrome accurately.